κ-Opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration
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چکیده
منابع مشابه
Administration of MDMA to ethanol-deprived rats increases ethanol operant self-administration and dopamine release during reinstatement.
Recreational use of (±)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is often associated with other drugs, among which ethanol (EtOH) is one of the most common. However, little is known about how neurochemical sensitization produced by MDMA can modulate EtOH abuse. In this study we used EtOH operant self-administration tasks to investigate the effect of several low doses (0.33, 1.0 and 3.0...
متن کاملMicrodialysis of ethanol during operant ethanol self-administration and ethanol determination by gas chromatography.
Operant self-administration methods are commonly used to study the behavioral and pharmacological effects of many drugs of abuse, including ethanol. However, ethanol is typically self-administered orally, rather than intravenously like many other drugs of abuse. The pharmacokinetics of orally administered drugs are more complex than intravenously administered drugs. Because understanding the re...
متن کاملCannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers.
AIM To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10% v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical...
متن کاملRelationship between dopamine D2 receptor-associated responses and operant ethanol self-administration in the rat: a factor analysis.
AIMS To characterize the relationship between dopamine D(2) receptor-associated responses and operant ethanol self-administration in Wistar rats. METHODS Thirty-two rats were first tested for apomorphine-induced sniffing and raclopride-induced catalepsy. Subsequently, the same subjects were initiated to lever press for ethanol in the sucrose-fading procedure. The subjects were allowed to resp...
متن کاملEffect of operant self-administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens.
Although operant ethanol self-administration can increase accumbal dopamine activity, the relationship between dopamine and ethanol levels during consumption remains unclear. We trained Long-Evans rats to self-administer escalating concentrations of ethanol (with 10% sucrose) over 7 days, during which two to four lever presses resulted in 20 min of access to the solution with no further respons...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2006
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2006.04.005